SecondLook is built for people navigating undiagnosed illness — the ones who’ve been told “I don’t know” or “it’s probably nothing” one too many times. For over 40% of cases, we name the correct diagnosis as the #1 match, so you can bring it to your doctor and ask — “could this be it?”
Get Your Analysis — FreeYou’ve seen multiple specialists over months or years and still don’t have an answer that fits.
Your child has symptoms no one seems to connect. You’re looking for a way to think through the possibilities.
You have a diagnosis, but symptoms it doesn’t explain. You want a second look at the picture.
This analysis is AI-generated and is for educational purposes only. It does not replace professional medical advice, diagnosis, or treatment. Always consult with qualified healthcare providers for medical decisions, especially before acting on any AI-suggested diagnosis or test.
Here’s what happens after you tell us your story: nine steps that turn it into a ranked list of possibilities and the specific tests that could confirm each one.
Each evaluation takes 8–10 minutes on average.
On real published rare-disease cases — the same benchmark used in peer-reviewed research evaluating diagnostic AI.
We’re not a chatbot — we’re a diagnostic pipeline built for rare disease.
Instead of asking one AI for an answer, SecondLook runs your case through the 5 most relevant AI specialists in parallel, grounded in a knowledge base of 9,275 rare-disease profiles, and scores each candidate against formal diagnostic criteria. On the same rare-disease cases, we’re 30–35% more accurate at the #1 match than a single query to OpenAI o3 or Claude Opus 4.7.
Guides on rare-disease diagnosis, navigating complex medical cases, and making the most of AI symptom checkers on your health journey.
Acromegaly mimics arthritis, sleep apnea, and aging for a decade. Learn the symptom checklist, why doctors miss it, and how to get the right IGF-1 test.
IIH, Chiari malformation, and migraine are routinely misdiagnosed as each other. Learn the key differences, red flags, and how to advocate for the right diagnosis.
Still getting hives and no answers? Learn why mastocytosis and MCAS are routinely misdiagnosed as allergies or anxiety — and what the real diagnostic criteria look like.
Ten minutes of your time. A ranked list of what might be going on, and the specific tests that could confirm each one. Free while we’re in early access.
Get Your Analysis — Free#1-match accuracy and head-to-head comparisons measured on random samples of Phenopacket2Prompt vignettes, scored by an LLM tier grader applied uniformly across SecondLook, OpenAI o3, and Claude Opus 4.7. Full methodology footnotes appear inside the “How SecondLook compares” section above.